Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane Fusion
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Dynamic Viral Glycoprotein Machines: Approaches for Probing Transient States That Drive Membrane Fusion.
The fusion glycoproteins that decorate the surface of enveloped viruses undergo dramatic conformational changes in the course of engaging with target cells through receptor interactions and during cell entry. These refolding events ultimately drive the fusion of viral and cellular membranes leading to delivery of the genetic cargo. While well-established methods for structure determination such...
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ژورنال
عنوان ژورنال: Viruses
سال: 2016
ISSN: 1999-4915
DOI: 10.3390/v8010015